Following detailed analysis, NeoPhore prioritised the MutLα heterodimer proteins PMS2 and MLH1 as biological targets recognising their critical enzymatic activity for repair of an errant DNA daughter strand. PMS2 and MLH1 belong to the gyrase, Hsp90, histidine kinase, MutL (GHKL) ATPase family, of which Hsp90 has been the target of multiple drug discovery campaigns. Both PMS2 and MLH1 contain an N-terminal ATPase domain (NTD), a C-terminal dimerization domain (CTD) and a flexible linker domain. In the case of PMS2, but not MLH1, the CTD harbours the endonuclease activity essential for editing out DNA replication errors.